Decoralin [AC1]

General Information


DRACP ID  DRACP02201

Peptide Name   Decoralin [AC1]

Sequence  RLLRLIRKLII

Sequence Length  11

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic (Derived from Decoralin)

Type  Synthetic peptide

Classification

  

Active ACP Membrane lysis Cell-penetrating peptides



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type Carcinoma EC50=11±1 μM MTT assay 24/72 h 1
A549 Lung adenocarcinoma Carcinoma EC50=21±1 μM MTT assay 24/72 h 1
1205Lu Melanoma Carcinoma EC50=9±1 μM MTT assay 24/72 h 1
Jurkat Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia Leukemia EC50=39±1 μM MTT assay 24/72 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HDMEC: EC50=141±1 μM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02201

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C66H127N21O12

Absent amino acids  ACDEFGHMNPQSTVWY

Common amino acids  L

Mass  158543

Pl  12.81

Basic residues  4

Acidic residues  0

Hydrophobic residues  7

Net charge  4

Boman Index  -1587

Hydrophobicity  102.73

Aliphatic Index  248.18

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 26119906

Title  Multidimensional Design of Anticancer Peptides

Doi 10.1002/anie.201504018

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.