This work is licensed under a Creative Commons Attribution 4.0 International License.
Decoralin [AC4]
General Information
DRACP ID DRACP02204
Peptide Name Decoralin [AC4]
Sequence YLLYLIRKLIL
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic (Derived from Decoralin)
Type Synthetic peptide
Classification
Active ACP Membrane lysis Cell-penetrating peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | EC50=13±1 μM | MTT assay | 24/72 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | EC50=29±1 μM | MTT assay | 24/72 h | 1 |
| 1205Lu | Melanoma | Carcinoma | EC50=14±1 μM | MTT assay | 24/72 h | 1 |
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | EC50=22±1 μM | MTT assay | 24/72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HDMEC: EC50=256±2 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C72H121N15O14
Absent amino acids ACDEFGHMNPQSTVW
Common amino acids L
Mass 159941
Pl 10.01
Basic residues 2
Acidic residues 0
Hydrophobic residues 7
Net charge 2
Boman Index 1369
Hydrophobicity 154.55
Aliphatic Index 248.18
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 2980
Absorbance 280nm 298
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26119906
Title Multidimensional Design of Anticancer Peptides
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.