This work is licensed under a Creative Commons Attribution 4.0 International License.
PL-D 4
General Information
DRACP ID DRACP02222
Peptide Name PL-D 4
Sequence RWRRKWWWW
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | IC50=73 µM | Resazurin assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C79H100N24O10
Absent amino acids ACDEFGHILMNPQSTVY
Common amino acids W
Mass 168868
Pl 12.81
Basic residues 4
Acidic residues 0
Hydrophobic residues 5
Net charge 4
Boman Index -3866
Hydrophobicity -243.33
Aliphatic Index 0
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 27500
Absorbance 280nm 3437.5
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23478953
Title Targeting Mycobacterium tuberculosis and other microbial pathogens using improved synthetic antibacterial peptides
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_7045
This work is licensed under a Creative Commons Attribution 4.0 International License.