This work is licensed under a Creative Commons Attribution 4.0 International License.
PL-D 46
General Information
DRACP ID DRACP02264
Peptide Name PL-D 46
Sequence RTKKWIVWI
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | IC50=208.3 µM | Resazurin assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C61H96N16O11
Absent amino acids ACDEFGHLMNPQSY
Common amino acids IKW
Mass 137241
Pl 11.82
Basic residues 3
Acidic residues 0
Hydrophobic residues 5
Net charge 3
Boman Index -1005
Hydrophobicity -17.78
Aliphatic Index 118.89
Half Life
Mammalian: 2.8 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 1375
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23478953
Title Targeting Mycobacterium tuberculosis and other microbial pathogens using improved synthetic antibacterial peptides
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_7091
This work is licensed under a Creative Commons Attribution 4.0 International License.