This work is licensed under a Creative Commons Attribution 4.0 International License.
Tyrocidine A, TrcA
General Information
DRACP ID DRACP02268
Peptide Name Tyrocidine A, TrcA
Sequence VXLfPFfNQY
Sequence Length 10
UniProt ID Not available
PubChem CID 16129635
Origin Bacillus subtilis; Bacillus aneurinolyticus; Bacillus brevis
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | LC50=21 µM | Resazurin assay | 24 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | LC50=14 µM | Resazurin assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=4.5 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Val1<--->Tyr10
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=Orn; f=D-Phe
Chiral Mix
Physicochemical Information
Formula C43H55N9O8
Absent amino acids ACDEGHIKMRSTW
Common amino acids FLNPQVYX
Mass 109667
Pl 6.09
Basic residues 0
Acidic residues 0
Hydrophobic residues 3
Net charge 0
Boman Index -38
Hydrophobicity 9
Aliphatic Index 68
Half Life
/
Extinction Coefficient cystines 1490
Absorbance 280nm 165.56
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17462586
Title Inhibition of malaria parasite blood stages by tyrocidines, membrane-active cyclic peptide antibiotics from Bacillus brevis
Doi 10.1016/j.bbamem.2007.01.015
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_3316
This work is licensed under a Creative Commons Attribution 4.0 International License.