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Tyrocidine A1, TrcA1
General Information
DRACP ID DRACP02269
Peptide Name Tyrocidine A1, TrcA1
Sequence VKLfPFfNQY
Sequence Length 10
UniProt ID Not available
PubChem CID 45485347
Origin Bacillus aneurinolyticus; Bacillus brevis
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | LC50=15 µM | Resazurin assay | 24 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | LC50=12 µM | Resazurin assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=4.1 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Val1<--->Tyr10
N-terminal Modification Free
C-terminal Modification Free
Other Modification f=D-Phe
Chiral Mix
Physicochemical Information
Formula C49H69N11O10
Absent amino acids ACDEGHIMRSTW
Common amino acids FKLNPQVY
Mass 113286
Pl 9.3
Basic residues 1
Acidic residues 0
Hydrophobic residues 3
Net charge 1
Boman Index -593
Hydrophobicity -30
Aliphatic Index 68
Half Life
/
Extinction Coefficient cystines 1490
Absorbance 280nm 165.56
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17462586
Title Inhibition of malaria parasite blood stages by tyrocidines, membrane-active cyclic peptide antibiotics from Bacillus brevis
Doi 10.1016/j.bbamem.2007.01.015
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_6090
This work is licensed under a Creative Commons Attribution 4.0 International License.