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Tyrocidine B, TrcB
General Information
DRACP ID DRACP02270
Peptide Name Tyrocidine B, TrcB
Sequence VXLfPWfNQY
Sequence Length 10
UniProt ID Not available
PubChem CID 16160723
Origin Bacillus aneurinolyticus; Bacillus brevis
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | LC50=17 µM | Resazurin assay | 24 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | LC50=12 µM | Resazurin assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=2.6 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Val1<--->Tyr10
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=Orn; f=D-Phe
Chiral Mix
Physicochemical Information
Formula C45H56N10O8
Absent amino acids ACDEFGHIKMRST
Common amino acids LNPQVWYX
Mass 113571
Pl 6.09
Basic residues 0
Acidic residues 0
Hydrophobic residues 3
Net charge 0
Boman Index -103
Hydrophobicity -28
Aliphatic Index 68
Half Life
/
Extinction Coefficient cystines 6990
Absorbance 280nm 776.67
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17462586
Title Inhibition of malaria parasite blood stages by tyrocidines, membrane-active cyclic peptide antibiotics from Bacillus brevis
Doi 10.1016/j.bbamem.2007.01.015
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_6091
This work is licensed under a Creative Commons Attribution 4.0 International License.