Tyrocidine B, TrcB

General Information


DRACP ID  DRACP02270

Peptide Name   Tyrocidine B, TrcB

Sequence  VXLfPWfNQY

Sequence Length  10

UniProt ID  Not available

PubChem CID  16160723 

Origin  Bacillus aneurinolyticus; Bacillus brevis

Type  Native peptide

Classification

  

Active ACP Membrane lysis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma LC50=17 µM Resazurin assay 24 h 1
A549 Lung adenocarcinoma Carcinoma LC50=12 µM Resazurin assay 24 h 1

Hemolytic Activity  Human erythrocytes: 50% Hemolysis=2.6 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antimicrobial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Val1<--->Tyr10

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X=Orn; f=D-Phe

Chiral  Mix



Physicochemical Information


Formula  C45H56N10O8

Absent amino acids  ACDEFGHIKMRST

Common amino acids  LNPQVWYX

Mass  113571

Pl  6.09

Basic residues  0

Acidic residues  0

Hydrophobic residues  3

Net charge  0

Boman Index  -103

Hydrophobicity  -28

Aliphatic Index  68

Half Life 
  /

Extinction Coefficient cystines  6990

Absorbance 280nm  776.67

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 17462586

Title  Inhibition of malaria parasite blood stages by tyrocidines, membrane-active cyclic peptide antibiotics from Bacillus brevis

Doi 10.1016/j.bbamem.2007.01.015

Year  2007

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPN_6091

DRACP is developed by Dr.Zheng's team.