This work is licensed under a Creative Commons Attribution 4.0 International License.
Tyrocidine B1, TrcB1
General Information
DRACP ID DRACP02271
Peptide Name Tyrocidine B1, TrcB1
Sequence VKLfPWfNQY
Sequence Length 10
UniProt ID Not available
PubChem CID 45485348
Origin Bacillus aneurinolyticus; Bacillus brevis
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | LC50=28 µM | Resazurin assay | 24 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | LC50=24 µM | Resazurin assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=8.6 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Val1<--->Tyr10
N-terminal Modification Free
C-terminal Modification Free
Other Modification f=D-Phe
Chiral Mix
Physicochemical Information
Formula C51H70N12O10
Absent amino acids ACDEFGHIMRST
Common amino acids KLNPQVWY
Mass 117190
Pl 9.3
Basic residues 1
Acidic residues 0
Hydrophobic residues 3
Net charge 1
Boman Index -658
Hydrophobicity -67
Aliphatic Index 68
Half Life
/
Extinction Coefficient cystines 6990
Absorbance 280nm 776.67
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17462586
Title Inhibition of malaria parasite blood stages by tyrocidines, membrane-active cyclic peptide antibiotics from Bacillus brevis
Doi 10.1016/j.bbamem.2007.01.015
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_6092
This work is licensed under a Creative Commons Attribution 4.0 International License.