This work is licensed under a Creative Commons Attribution 4.0 International License.
Hp1090
General Information
DRACP ID DRACP02274
Peptide Name Hp1090
Sequence IFKAIWSGIKSLF
Sequence Length 13
PubChem CID 71589252
Origin Heterometrus petersii; Urodacus manicatus
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Huh7.5.1 | Adult hepatocellular carcinoma | Carcinoma | Cell viability>90%: Concentration<20 μg/ml | MTT assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C76H116N16O16
Absent amino acids CDEHMNPQRTVY
Common amino acids I
Mass 172408
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 8
Net charge 2
Boman Index 1282
Hydrophobicity 107.69
Aliphatic Index 127.69
Half Life
Mammalian: 100 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 458.33
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 20950663
Title A new natural α-helical peptide from the venom of the scorpion Heterometrus petersii kills HCV
Doi 10.1016/j.peptides.2010.10.008
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3353
This work is licensed under a Creative Commons Attribution 4.0 International License.