This work is licensed under a Creative Commons Attribution 4.0 International License.
[Lys]1-VmCT1-NH2
General Information
DRACP ID DRACP02278
Peptide Name [Lys]1-VmCT1-NH2
Sequence KLGALWNVAKSVF
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | >100 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: ~0% Hemolytic=12.5 µM
Normal (non-cancerous) Cytotoxicity MCF-10A: Not active up to 25 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C69H109N17O16
Absent amino acids CDEHIMPQRTY
Common amino acids AKLV
Mass 164696
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 8
Net charge 2
Boman Index 665
Hydrophobicity 69.23
Aliphatic Index 120
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 458.33
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31181304
Title The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1
Doi 10.1016/j.ejps.2019.06.006
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16788
This work is licensed under a Creative Commons Attribution 4.0 International License.