This work is licensed under a Creative Commons Attribution 4.0 International License.
Pantinin-1
General Information
DRACP ID DRACP02287
Peptide Name Pantinin-1
Sequence GILGKLWEGFKSIV
Sequence Length 14
UniProt ID R4JNJ5
PubChem CID 102602714
Origin Pandinus imperator
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=28.5 ± 1.0 μM | MTS assay | 24 h | 1 |
| DU145 | Prostate carcinoma | Carcinoma | IC50=47.5 ± 2.0 μM | MTS assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HGF-1: IC50=97.5 ± 1.0 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C75H119N17O18
Absent amino acids ACDHMNPQRTY
Common amino acids G
Mass 177894
Pl 9.54
Basic residues 2
Acidic residues 1
Hydrophobic residues 7
Net charge 1
Boman Index 1054
Hydrophobicity 67.14
Aliphatic Index 132.14
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 423.08
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30409511
Title Biophysical characterization and antitumor activity of synthetic Pantinin peptides from scorpion's venom
Doi 10.1016/j.bbamem.2018.08.012
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3490
This work is licensed under a Creative Commons Attribution 4.0 International License.