This work is licensed under a Creative Commons Attribution 4.0 International License.
Pantinin-2
General Information
DRACP ID DRACP02288
Peptide Name Pantinin-2
Sequence IFGAIWKGISSLL
Sequence Length 13
UniProt ID R4JQZ0
PubChem CID 102602715
Origin Pandinus imperator
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=12.5 ± 1.0 μM | MTS assay | 24 h | 1 |
| DU145 | Prostate carcinoma | Carcinoma | IC50=16.5 ± 1.0 μM | MTS assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HGF-1: IC50=43.5 ± 2.0 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C69H109N15O16
Absent amino acids CDEHMNPQRTVY
Common amino acids I
Mass 161895
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 8
Net charge 1
Boman Index 2125
Hydrophobicity 142.31
Aliphatic Index 157.69
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 458.33
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30409511
Title Biophysical characterization and antitumor activity of synthetic Pantinin peptides from scorpion's venom
Doi 10.1016/j.bbamem.2018.08.012
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3489
This work is licensed under a Creative Commons Attribution 4.0 International License.