Pantinin-2

General Information


DRACP ID  DRACP02288

Peptide Name   Pantinin-2

Sequence  IFGAIWKGISSLL

Sequence Length  13

UniProt ID  R4JQZ0 

PubChem CID  102602715 

Origin  Pandinus imperator

Type  Native peptide

Classification

  

Active ACP Membrane lysis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MDA-MB-231 Breast adenocarcinoma Carcinoma IC50=12.5 ± 1.0 μM MTS assay 24 h 1
DU145 Prostate carcinoma Carcinoma IC50=16.5 ± 1.0 μM MTS assay 24 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HGF-1: IC50=43.5 ± 2.0 μM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antimicrobial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02288

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C69H109N15O16

Absent amino acids  CDEHMNPQRTVY

Common amino acids  I

Mass  161895

Pl  9.7

Basic residues  1

Acidic residues  0

Hydrophobic residues  8

Net charge  1

Boman Index  2125

Hydrophobicity  142.31

Aliphatic Index  157.69

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  458.33

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30409511

Title  Biophysical characterization and antitumor activity of synthetic Pantinin peptides from scorpion's venom

Doi 10.1016/j.bbamem.2018.08.012

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPR_3489

DRACP is developed by Dr.Zheng's team.