This work is licensed under a Creative Commons Attribution 4.0 International License.
Pantinin-3
General Information
DRACP ID DRACP02289
Peptide Name Pantinin-3
Sequence FLSTIWNGIKSLL
Sequence Length 13
UniProt ID R4JJN6
PubChem CID 102602716
Origin Pandinus imperator
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=13.5 ± 2.0 μM | MTS assay | 24 h | 1 |
| DU145 | Prostate carcinoma | Carcinoma | IC50=17.3 ± 1.0 μM | MTS assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HGF-1: IC50=26.0 ± 1.0 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C72H114N16O18
Absent amino acids ACDEHMPQRVY
Common amino acids L
Mass 170602
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 7
Net charge 1
Boman Index 929
Hydrophobicity 93.85
Aliphatic Index 150
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 458.33
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30409511
Title Biophysical characterization and antitumor activity of synthetic Pantinin peptides from scorpion's venom
Doi 10.1016/j.bbamem.2018.08.012
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3431
This work is licensed under a Creative Commons Attribution 4.0 International License.