This work is licensed under a Creative Commons Attribution 4.0 International License.
Brevinin-1BYa
General Information
DRACP ID DRACP02290
Peptide Name Brevinin-1BYa
Sequence FLPILASLAAKFGPKLFCLVTKKC
Sequence Length 24
PubChem CID Not available
Origin Rana boylii
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | LC50=6 μM | CytoTox 96 non-radiactive cytotoxicity assay | 1 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | LC50=9 μM | CellTiter-Glo Luminescent Cell Viability assay | 24, 48 h | 1 |
Hemolytic Activity Human erythrocytes: LC50=10 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys18<--->Cys24
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C126H206N28O27S2
Absent amino acids DEHMNQRWY
Common amino acids L
Mass 301976
Pl 10.35
Basic residues 4
Acidic residues 0
Hydrophobic residues 13
Net charge 4
Boman Index 2326
Hydrophobicity 107.5
Aliphatic Index 122.08
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 5.43
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21312033
Title Synthesis, conformational analysis and biological properties of a dicarba derivative of the antimicrobial peptide, brevinin-1BYa
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3536
This work is licensed under a Creative Commons Attribution 4.0 International License.