DC-brevinin-1BYa, peak 1

General Information


DRACP ID  DRACP02291

Peptide Name   DC-brevinin-1BYa, peak 1

Sequence  FLPILASLAAKFGPKLFXLVTKKX

Sequence Length  24

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HepG2 Hepatoblastoma Blastoma LC50=4 μM CytoTox 96 non-radiactive cytotoxicity assay  1 h 1
MDA-MB-231 Breast adenocarcinoma Carcinoma LC50=7 μM CellTiter-Glo Luminescent Cell Viability assay 24, 48 h 1

Hemolytic Activity  Human erythrocytes: LC50=4 μM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antimicrobial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  DCB: X18<--->X24

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X=Allylglycine

Chiral  L



Physicochemical Information


Formula  C120H192N26O23

Absent amino acids  CDEHMNQRWY

Common amino acids  L

Mass  299744

Pl  11.28

Basic residues  4

Acidic residues  0

Hydrophobic residues  13

Net charge  4

Boman Index  2070

Hydrophobicity  86.67

Aliphatic Index  122.08

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 21312033

Title  Synthesis, conformational analysis and biological properties of a dicarba derivative of the antimicrobial peptide, brevinin-1BYa

Doi 10.1007/s00249-011-0679-2

Year  2011

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.