This work is licensed under a Creative Commons Attribution 4.0 International License.
DC-brevinin-1BYa, peak 1
General Information
DRACP ID DRACP02291
Peptide Name DC-brevinin-1BYa, peak 1
Sequence FLPILASLAAKFGPKLFXLVTKKX
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | LC50=4 μM | CytoTox 96 non-radiactive cytotoxicity assay | 1 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | LC50=7 μM | CellTiter-Glo Luminescent Cell Viability assay | 24, 48 h | 1 |
Hemolytic Activity Human erythrocytes: LC50=4 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond DCB: X18<--->X24
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=Allylglycine
Chiral L
Physicochemical Information
Formula C120H192N26O23
Absent amino acids CDEHMNQRWY
Common amino acids L
Mass 299744
Pl 11.28
Basic residues 4
Acidic residues 0
Hydrophobic residues 13
Net charge 4
Boman Index 2070
Hydrophobicity 86.67
Aliphatic Index 122.08
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21312033
Title Synthesis, conformational analysis and biological properties of a dicarba derivative of the antimicrobial peptide, brevinin-1BYa
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.