This work is licensed under a Creative Commons Attribution 4.0 International License.
Mucroporin-M1
General Information
DRACP ID DRACP02294
Peptide Name Mucroporin-M1
Sequence LFRLIKSLIKRLVSAFK
Sequence Length 17
UniProt ID B9UIY3
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa-ACE2 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 50% Cytotoxicity=61.58 µg/ml | MTT assay | 24 h | 1 |
| HepG2.2.15 | Hepatoblastoma | Blastoma | 50% Cytotoxicity=87 µM | MTT assay | 48 h | 2 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Vero cells: 50% Cytotoxicity=70.46 µg/ml; MDCK: 50% Cytotoxicity=83.35 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C98H170N26O20
Absent amino acids CDEGHMNPQTWY
Common amino acids L
Mass 231816
Pl 12.55
Basic residues 5
Acidic residues 0
Hydrophobic residues 10
Net charge 5
Boman Index -1196
Hydrophobicity 79.41
Aliphatic Index 160.59
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21620914
Title Virucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses
Doi 10.1016/j.peptides.2011.05.015
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_3753
This work is licensed under a Creative Commons Attribution 4.0 International License.