This work is licensed under a Creative Commons Attribution 4.0 International License.
Hymenochirin-1B
General Information
DRACP ID DRACP02295
Peptide Name Hymenochirin-1B
Sequence IKLSPETKDNLKKVLKGAIKGAIAVAKMV
Sequence Length 29
PubChem CID Not available
Origin Hymenochirus boettgeri
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | LC50=2.5 ± 0.2 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | LC50=9.0 ± 0.3 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | LC50=9.7 ± 0.2 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
| HepG2 | Hepatoblastoma | Blastoma | LC50=22.5 ± 1.4 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=15.22±0.21 μM | MTT assay | 96 h | 2 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=12.76±0.43 μM | MTT assay | 96 h | 2 |
| HepG2 | Hepatoblastoma | Blastoma | IC50=8.07±0.21 μM | MTT assay | 96 h | 2 |
Hemolytic Activity Human erythrocytes: LC50=213 ± 18 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C139H251N37O37S
Absent amino acids CFHQRWY
Common amino acids K
Mass 356445
Pl 10.93
Basic residues 7
Acidic residues 2
Hydrophobic residues 13
Net charge 5
Boman Index -1388
Hydrophobicity 16.9
Aliphatic Index 124.48
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24185042
Title Anti-tumor activities of the host-defense peptide hymenochirin-1B
Doi 10.1016/j.regpep.2013.10.006
Year 2013
Literature 2
Pubmed ID 30789695
Title Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy
Doi 10.1021/acschembio.9b00046
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3785
This work is licensed under a Creative Commons Attribution 4.0 International License.