This work is licensed under a Creative Commons Attribution 4.0 International License.
Hymenochirin-3B
General Information
DRACP ID DRACP02297
Peptide Name Hymenochirin-3B
Sequence IKIPAVVKDTLKKVAKGVLSAVAGALTQ
Sequence Length 28
UniProt ID W8NZ39 W8PA72 W8P6R9 W8NYV9 W8PRB1 W8NYW4 W8PA77 W8P6S4 W8PRB6 W8NZ42
PubChem CID Not available
Origin Hymenochirus boettgeri
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | LC50=8.8 ± 0.7 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | LC50=21.2 ± 2.0 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | LC50=33.0 ± 2.2 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
| HepG2 | Hepatoblastoma | Blastoma | LC50=47.9 ± 1.8 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: LC50> 400 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C129H232N34O35
Absent amino acids CEFHMNRWY
Common amino acids AKV
Mass 330128
Pl 10.98
Basic residues 5
Acidic residues 1
Hydrophobic residues 15
Net charge 4
Boman Index 518
Hydrophobicity 68.93
Aliphatic Index 139.29
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24185042
Title Anti-tumor activities of the host-defense peptide hymenochirin-1B
Doi 10.1016/j.regpep.2013.10.006
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3787
This work is licensed under a Creative Commons Attribution 4.0 International License.