This work is licensed under a Creative Commons Attribution 4.0 International License.
Hymenochirin-4B
General Information
DRACP ID DRACP02298
Peptide Name Hymenochirin-4B
Sequence IKIPAFVKDTLKKVAKGVISAVAGALTQ
Sequence Length 28
UniProt ID W8NYW4
PubChem CID Not available
Origin Hymenochirus boettgeri
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | LC50=5.9 ± 0.6 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | LC50=11.0 ± 1.7 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | LC50=14.8 ± 2.0 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
| HepG2 | Hepatoblastoma | Blastoma | LC50=28.4 ± 0.4 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: LC50=158 ± 6 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C133H232N34O35
Absent amino acids CEHMNRWY
Common amino acids AK
Mass 334932
Pl 10.98
Basic residues 5
Acidic residues 1
Hydrophobic residues 15
Net charge 4
Boman Index 412
Hydrophobicity 66.43
Aliphatic Index 128.93
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24185042
Title Anti-tumor activities of the host-defense peptide hymenochirin-1B
Doi 10.1016/j.regpep.2013.10.006
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3788
This work is licensed under a Creative Commons Attribution 4.0 International License.