This work is licensed under a Creative Commons Attribution 4.0 International License.
Hymenochirin-1B [E6K]
General Information
DRACP ID DRACP02300
Peptide Name Hymenochirin-1B [E6K]
Sequence IKLSPKTKDNLKKVLKGAIKGAIAVAKMV
Sequence Length 29
UniProt ID Not available
PubChem CID Not available
Origin Synthetic (Derived from Hymenochirin-1B)
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | LC50=1.2 ± 0.1 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: LC50=186 ± 4 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C140H256N38O35S
Absent amino acids CEFHQRWY
Common amino acids K
Mass 356351
Pl 11.28
Basic residues 8
Acidic residues 1
Hydrophobic residues 13
Net charge 7
Boman Index -1262
Hydrophobicity 15.52
Aliphatic Index 124.48
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24185042
Title Anti-tumor activities of the host-defense peptide hymenochirin-1B
Doi 10.1016/j.regpep.2013.10.006
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4421
This work is licensed under a Creative Commons Attribution 4.0 International License.