This work is licensed under a Creative Commons Attribution 4.0 International License.
Hymenochirin-1B [E6K,D9K]
General Information
DRACP ID DRACP02304
Peptide Name Hymenochirin-1B [E6K,D9K]
Sequence IKLSPKTKKNLKKVLKGAIKGAIAVAKMV
Sequence Length 29
UniProt ID Not available
PubChem CID Not available
Origin
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | LC50=1.0 ± 0.1 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: LC50=85 ± 5 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C142H263N39O33S
Absent amino acids CDEFHQRWY
Common amino acids K
Mass 357659
Pl 11.7
Basic residues 9
Acidic residues 0
Hydrophobic residues 13
Net charge 9
Boman Index -945
Hydrophobicity 14.14
Aliphatic Index 124.48
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24185042
Title Anti-tumor activities of the host-defense peptide hymenochirin-1B
Doi 10.1016/j.regpep.2013.10.006
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4425
This work is licensed under a Creative Commons Attribution 4.0 International License.