Hymenochirin-1B [E6k,D9k]

General Information


DRACP ID  DRACP02307

Peptide Name   Hymenochirin-1B [E6k,D9k]

Sequence  IKLSPkTKkNLKKVLKGAIKGAIAVAKMV

Sequence Length  29

UniProt ID  Not available

PubChem CID  Not available

Origin 

Type  Synthetic peptide

Classification

  

Active ACP Membrane lysis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A549 Lung adenocarcinoma Carcinoma LC50=2.1 ± 0.1 μM CellTiter-Glo Luminescent Cell Viability assay 24 h 1
MDA-MB-231 Breast adenocarcinoma Carcinoma LC50=5.2 ± 0.3 μM CellTiter-Glo Luminescent Cell Viability assay 24 h 1
HT-29 Colon adenocarcinoma Carcinoma LC50=15.1 ± 0.5 μM CellTiter-Glo Luminescent Cell Viability assay 24 h 1
HepG2 Hepatoblastoma Blastoma LC50=4.1 ± 0.7 μM CellTiter-Glo Luminescent Cell Viability assay 24 h 1

Hemolytic Activity  Human erythrocytes: LC50=302 ± 21 μM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  k=D-Lys

Chiral  Mix



Physicochemical Information


Formula  C130H235N35O29S

Absent amino acids  CDEFHQRWY

Common amino acids  K

Mass  328421

Pl  11.58

Basic residues  7

Acidic residues  0

Hydrophobic residues  13

Net charge  7

Boman Index  165

Hydrophobicity  41.03

Aliphatic Index  124.48

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  5

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 24185042

Title  Anti-tumor activities of the host-defense peptide hymenochirin-1B

Doi 10.1016/j.regpep.2013.10.006

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.