This work is licensed under a Creative Commons Attribution 4.0 International License.
Hymenochirin-1B [E6k,D9k]
General Information
DRACP ID DRACP02307
Peptide Name Hymenochirin-1B [E6k,D9k]
Sequence IKLSPkTKkNLKKVLKGAIKGAIAVAKMV
Sequence Length 29
UniProt ID Not available
PubChem CID Not available
Origin
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | LC50=2.1 ± 0.1 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | LC50=5.2 ± 0.3 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | LC50=15.1 ± 0.5 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
| HepG2 | Hepatoblastoma | Blastoma | LC50=4.1 ± 0.7 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: LC50=302 ± 21 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification k=D-Lys
Chiral Mix
Physicochemical Information
Formula C130H235N35O29S
Absent amino acids CDEFHQRWY
Common amino acids K
Mass 328421
Pl 11.58
Basic residues 7
Acidic residues 0
Hydrophobic residues 13
Net charge 7
Boman Index 165
Hydrophobicity 41.03
Aliphatic Index 124.48
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24185042
Title Anti-tumor activities of the host-defense peptide hymenochirin-1B
Doi 10.1016/j.regpep.2013.10.006
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.