Granulysin (23-51) [C34S][C45S]

General Information


DRACP ID  DRACP02309

Peptide Name   Granulysin (23-51) [C34S][C45S]

Sequence  QRSVSNAATRVSRTGRSRWRDVSRNFMRR

Sequence Length  29

UniProt ID  P22749 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Induce apoptosis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
Jurkat Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia Leukemia Not active at 20 µM PI assay 4 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antimicrobial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02309

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C142H242N60O42S

Absent amino acids  CEHIKLPY

Common amino acids  R

Mass  399348

Pl  13.04

Basic residues  9

Acidic residues  1

Hydrophobic residues  7

Net charge  8

Boman Index  -15962

Hydrophobicity  -138.97

Aliphatic Index  36.9

Half Life 
  Mammalian: 0.8 hour
  Yeast: 10 min
  E.coli: >10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  196.43

Polar residues  10

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 10903754

Title  Bactericidal and tumoricidal activities of synthetic peptides derived from granulysin

Doi 10.4049/jimmunol.165.3.1486

Year  2000

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_3868

DRACP is developed by Dr.Zheng's team.