This work is licensed under a Creative Commons Attribution 4.0 International License.
Granulysin (23-51) [C34S][C45S]
General Information
DRACP ID DRACP02309
Peptide Name Granulysin (23-51) [C34S][C45S]
Sequence QRSVSNAATRVSRTGRSRWRDVSRNFMRR
Sequence Length 29
UniProt ID P22749
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | Not active at 20 µM | PI assay | 4 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C142H242N60O42S
Absent amino acids CEHIKLPY
Common amino acids R
Mass 399348
Pl 13.04
Basic residues 9
Acidic residues 1
Hydrophobic residues 7
Net charge 8
Boman Index -15962
Hydrophobicity -138.97
Aliphatic Index 36.9
Half Life
Mammalian: 0.8 hour
Yeast: 10 min
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 196.43
Polar residues 10
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 10903754
Title Bactericidal and tumoricidal activities of synthetic peptides derived from granulysin
Doi 10.4049/jimmunol.165.3.1486
Year 2000
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_3868
This work is licensed under a Creative Commons Attribution 4.0 International License.