This work is licensed under a Creative Commons Attribution 4.0 International License.
Granulysin (42-61)
General Information
DRACP ID DRACP02312
Peptide Name Granulysin (42-61)
Sequence RDVCRNFMRRYQSRVIQGLV
Sequence Length 20
UniProt ID P22749
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | 20% Cell death=20 µM | PI assay | 4 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C106H178N38O28S2
Absent amino acids AEHKPTW
Common amino acids R
Mass 283601
Pl 11.91
Basic residues 5
Acidic residues 1
Hydrophobic residues 6
Net charge 4
Boman Index -7507
Hydrophobicity -54.5
Aliphatic Index 82.5
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 1490
Absorbance 280nm 78.42
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 10903754
Title Bactericidal and tumoricidal activities of synthetic peptides derived from granulysin
Doi 10.4049/jimmunol.165.3.1486
Year 2000
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_3871
This work is licensed under a Creative Commons Attribution 4.0 International License.