Granulysin (37-51)

General Information


DRACP ID  DRACP02314

Peptide Name   Granulysin (37-51)

Sequence  GRSRWRDVCRNFMRR

Sequence Length  15

UniProt ID  P22749 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Induce apoptosis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
Jurkat Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia Leukemia 50% Cell death=20 µM PI assay 4 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antimicrobial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02314

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C82H135N35O20S2

Absent amino acids  AEHIKLPQTY

Common amino acids  R

Mass  224519

Pl  12.5

Basic residues  6

Acidic residues  1

Hydrophobic residues  3

Net charge  5

Boman Index  -9436

Hydrophobicity  -164.67

Aliphatic Index  19.33

Half Life 
  Mammalian: 0.8 hour
  Yeast: 10 min
  E.coli: >10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  392.86

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 10903754

Title  Bactericidal and tumoricidal activities of synthetic peptides derived from granulysin

Doi 10.4049/jimmunol.165.3.1486

Year  2000

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_3873

DRACP is developed by Dr.Zheng's team.