This work is licensed under a Creative Commons Attribution 4.0 International License.
Granulysin (37-51) [R38Q][R40Q]
General Information
DRACP ID DRACP02315
Peptide Name Granulysin (37-51) [R38Q][R40Q]
Sequence GQSQWRDVCRNFMRR
Sequence Length 15
UniProt ID P22749
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | Not active at 20 µM | PI assay | 4 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C80H127N31O22S2
Absent amino acids AEHIKLPTY
Common amino acids R
Mass 218909
Pl 12.02
Basic residues 4
Acidic residues 1
Hydrophobic residues 3
Net charge 3
Boman Index -7560
Hydrophobicity -151.33
Aliphatic Index 19.33
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 392.86
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 10903754
Title Bactericidal and tumoricidal activities of synthetic peptides derived from granulysin
Doi 10.4049/jimmunol.165.3.1486
Year 2000
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_3874
This work is licensed under a Creative Commons Attribution 4.0 International License.