Peptide Libraray

AamAP1

General Information

DRACP ID DRACP02316

Peptide Name AamAP1

Sequence FLFSLIPHAIGGLISAFK

Sequence Length 18

UniProt ID G8YYA5

PubChem CID 71595312

Origin Androctonus amoreuxi

Type Native peptide

Classification

Active ACP Membrane lysis

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
PC-3	Prostate carcinoma	Carcinoma	Not active at 150 µM	MTT assay	24 h	1
U251	Astrocytoma	Carcinoma	Not active at 150 µM	MTT assay	24 h	1
LNCaP	Prostate carcinoma	Carcinoma	Not active at 150 µM	MTT assay	24 h	1

Hemolytic Activity Horse erythrocytes: 100% Hemolysis=100 µM; 44.3% Hemolysis=80 µM

Normal (non-cancerous) Cytotoxicity HMEC-1: Not active up to 150 µM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial; Antifungal

Structure Information

PDB ID Not available

Predicted Structure DRACP02316

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C96H147N21O21

Absent amino acids CDEMNQRTVWY

Common amino acids FIL

Mass 223477

Pl 9.7

Basic residues 2

Acidic residues 0

Hydrophobic residues 11

Net charge 2

Boman Index 2695

Hydrophobicity 143.33

Aliphatic Index 141.11

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 4

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 22484288

Title Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog

Doi 10.1016/j.peptides.2012.03.016

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_3884