Peptide Libraray

AamAP2

General Information

DRACP ID DRACP02317

Peptide Name AamAP2

Sequence FPFSLIPHAIGGLISAIK

Sequence Length 18

UniProt ID G8YYA6

PubChem CID 71596346

Origin Androctonus amoreuxi

Type Native peptide

Classification

Active ACP Membrane lysis

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
PC-3	Prostate carcinoma	Carcinoma	Not active at 150 µM	MTT assay	24 h	1
U251	Astrocytoma	Carcinoma	Not active at 150 µM	MTT assay	24 h	1
LNCaP	Prostate carcinoma	Carcinoma	Not active at 150 µM	MTT assay	24 h	1

Hemolytic Activity Horse erythrocytes: 46% Hemolysis=100 µM; 37% Hemolysis=80 µM

Normal (non-cancerous) Cytotoxicity HMEC-1: Not active up to 150 µM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial; Antifungal

Structure Information

PDB ID Not available

Predicted Structure DRACP02317

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C92H145N21O21

Absent amino acids CDEMNQRTVWY

Common amino acids I

Mass 218471

Pl 9.7

Basic residues 2

Acidic residues 0

Hydrophobic residues 10

Net charge 2

Boman Index 2397

Hydrophobicity 122.78

Aliphatic Index 141.11

Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 4

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 22484288

Title Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog

Doi 10.1016/j.peptides.2012.03.016

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_3885