This work is licensed under a Creative Commons Attribution 4.0 International License.
AamAP-S1, AamAP1 [H8K]
General Information
DRACP ID DRACP02318
Peptide Name AamAP-S1, AamAP1 [H8K]
Sequence FLFSLIPKAIGGLISAFK
Sequence Length 18
UniProt ID G8YYA5
PubChem CID 71596347
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| PC-3 | Prostate carcinoma | Carcinoma | IC50=28 µM | MTT assay | 24 h | 1 |
| U251 | Astrocytoma | Carcinoma | IC50=29.23 µM | MTT assay | 24 h | 1 |
| LNCaP | Prostate carcinoma | Carcinoma | IC50=25.58 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Horse erythrocytes: 53% Hemolysis=100 µM; 52% Hemolysis=80 µM
Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=40.35 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C96H152N20O21
Absent amino acids CDEHMNQRTVWY
Common amino acids FIL
Mass 222580
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 11
Net charge 2
Boman Index 2606
Hydrophobicity 139.44
Aliphatic Index 141.11
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22484288
Title Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog
Doi 10.1016/j.peptides.2012.03.016
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3886
This work is licensed under a Creative Commons Attribution 4.0 International License.