This work is licensed under a Creative Commons Attribution 4.0 International License.
PLS-S4
General Information
DRACP ID DRACP02321
Peptide Name PLS-S4
Sequence FLSMIPHIVSGVAALAKHL
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Phyllomedusa sauvagii
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | IC50=23 µM | MTT assay | 72 h | 1 |
Hemolytic Activity Human erythrocytes: LC50=33 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C94H154N24O22S
Absent amino acids CDENQRTWY
Common amino acids AL
Mass 232573
Pl 9.7
Basic residues 3
Acidic residues 0
Hydrophobic residues 11
Net charge 3
Boman Index 2271
Hydrophobicity 131.58
Aliphatic Index 148.95
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23967105
Title Structure, antimicrobial activities and mode of interaction with membranes of novel [corrected] phylloseptins from the painted-belly leaf frog, Phyllomedusa sauvagii
Doi 10.1371/journal.pone.0070782
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.