This work is licensed under a Creative Commons Attribution 4.0 International License.
Maximin-H5, MH5N
General Information
DRACP ID DRACP02322
Peptide Name Maximin-H5, MH5N
Sequence ILGPVLGLVSDTLDDVLGIL
Sequence Length 20
UniProt ID Q8JHE1 B5L100 B5L135 C3RSW1 C3RSW6 C3RSX2 C3RSY2
PubChem CID Not available
Origin Bombina maxima
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| T98G | Glioblastoma | Blastoma | IC50=125 µM | CellTiter 96 AQueous One Solution Cell Proliferation Assay | 72 h | 1 |
Hemolytic Activity Human erythrocytes: 20% Hemolysis=90 µM
Normal (non-cancerous) Cytotoxicity SVGp12: ~10% Cell death=125 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C93H160N20O29
Absent amino acids ACEFHKMNQRWY
Common amino acids L
Mass 236153
Pl 3.34
Basic residues 0
Acidic residues 3
Hydrophobic residues 11
Net charge -3
Boman Index 2217
Hydrophobicity 148
Aliphatic Index 199.5
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28249727
Title Investigations into the potential anticancer activity of Maximin H5
Doi 10.1016/j.biochi.2017.02.013
Year 2017
Literature 2
Pubmed ID 25640709
Title The role of C-terminal amidation in the membrane interactions of the anionic antimicrobial peptide, maximin H5
Doi 10.1016/j.bbamem.2015.01.014
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3942
This work is licensed under a Creative Commons Attribution 4.0 International License.