This work is licensed under a Creative Commons Attribution 4.0 International License.
Bicarinalin
General Information
DRACP ID DRACP02323
Peptide Name Bicarinalin
Sequence KIKIPWGKVKDFLVGGMKAV
Sequence Length 20
UniProt ID W8GNV3
PubChem CID Not available
Origin Tetramorium bicarinatum
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| NCI-N87 | Gastric tubular adenocarcinoma | Carcinoma | 50% Cytotoxicity=1.7 µM | XTT assay | 24 h | 1 |
| RAW 264.7 | Mouse leukemia | Leukemia | 50% Cytotoxicity=39.2 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=720 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C106H176N26O23S
Absent amino acids CEHNQRSTY
Common amino acids K
Mass 255388
Pl 10.98
Basic residues 5
Acidic residues 1
Hydrophobic residues 9
Net charge 4
Boman Index 270
Hydrophobicity 26
Aliphatic Index 107
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 289.47
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29286296
Title Anti-Helicobacter pylori Properties of the Ant-Venom Peptide Bicarinalin
Year 2017
Literature 2
Pubmed ID 322960382
Title Identification and characterization of a novel antimicrobial peptide from the venom of the ant Tetramorium bicarinatum
Doi 10.1016/j.peptides.2012.08.018
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4107
This work is licensed under a Creative Commons Attribution 4.0 International License.