Peptide Libraray

m2163

General Information

DRACP ID DRACP02325

Peptide Name m2163

Sequence KRKCPKTPFDNTPGAWFAHLILGC

Sequence Length 24

UniProt ID Q036G0 K0N7G0 K6RXD6

PubChem CID Not available

Origin Lactobacillus casei; Lactobacillus paracasei

Type Native peptide

Classification

Active ACP Induce apoptosis

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
SW480	Colon adenocarcinoma	Carcinoma	IC50=40 µg/ml	MTT assay	24 h	1
BFTC-905	Bladder carcinoma	Carcinoma	~40% Cell death=40 µg/ml	MTT assay	24 h	1
CaCo-2	Colon adenocarcinoma	Carcinoma	~40% Cell death=40 µg/ml	MTT assay	24 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity H184B5F5/M10: ~20% Cell death=40 µg/ml; CHO-K1: ~40% Cell death=40 µg/ml

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antibacterial

Structure Information

PDB ID Not available

Predicted Structure DRACP02325

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys4<--->Cys24

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C124H190N34O30S2

Absent amino acids EMQSVY

Common amino acids KP

Mass 311164

Pl 9.67

Basic residues 5

Acidic residues 1

Hydrophobic residues 8

Net charge 4

Boman Index -2562

Hydrophobicity -33.33

Aliphatic Index 57.08

Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min

Extinction Coefficient cystines 5625

Absorbance 280nm 244.57

Polar residues 7

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 25557887

Title Antimicrobial peptide m2163 or m2386 identified from Lactobacillus casei ATCC 334 can trigger apoptosis in the human colorectal cancer cell line SW480

Doi 10.1007/s13277-014-3018-2

Year 2015

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_4143