Peptide Libraray

m2386

General Information

DRACP ID DRACP02326

Peptide Name m2386

Sequence DSIRDVSPTFNKIRRWFDGLFK

Sequence Length 22

UniProt ID Q035J6 K0MXK3

PubChem CID Not available

Origin Lactobacillus casei; Lactobacillus paracasei

Type Native peptide

Classification

Active ACP Induce apoptosis

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
SW480	Colon adenocarcinoma	Carcinoma	IC50=40 µg/ml	MTT assay	24 h	1
BFTC-905	Bladder carcinoma	Carcinoma	~40% Cell death=40 µg/ml	MTT assay	24 h	1
CaCo-3	Colon adenocarcinoma	Carcinoma	~40% Cell death=40 µg/ml	MTT assay	24 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity H184B5F5/M10: ~20% Cell death=40 µg/ml; CHO-K1: ~35% Cell death=40 µg/ml

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antibacterial

Structure Information

PDB ID Not available

Predicted Structure DRACP02326

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C124H189N35O33

Absent amino acids ACEHMQY

Common amino acids DFR

Mass 307282

Pl 10.76

Basic residues 5

Acidic residues 3

Hydrophobic residues 8

Net charge 2

Boman Index -6702

Hydrophobicity -68.64

Aliphatic Index 66.36

Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min

Extinction Coefficient cystines 5500

Absorbance 280nm 261.9

Polar residues 5

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 25557887

Title Antimicrobial peptide m2163 or m2386 identified from Lactobacillus casei ATCC 334 can trigger apoptosis in the human colorectal cancer cell line SW480

Doi 10.1007/s13277-014-3018-2

Year 2015

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_4142