This work is licensed under a Creative Commons Attribution 4.0 International License.
WAM-1
General Information
DRACP ID DRACP02328
Peptide Name WAM-1
Sequence KRGFGKKLRKRLKKFRNSIKKRLKNFNVVIPIPLPG
Sequence Length 36
UniProt ID B1NLN8
PubChem CID Not available
Origin Macropus eugenii
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse leukemia | Leukemia | Not active up to 128 µg/ml | CCK-8 assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: Not active up to 23.7 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C199H345N63O41
Absent amino acids ACDEHMQTWY
Common amino acids K
Mass 490077
Pl 13.13
Basic residues 14
Acidic residues 0
Hydrophobic residues 12
Net charge 14
Boman Index -9359
Hydrophobicity -81.67
Aliphatic Index 91.94
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 35474013
Title Antimicrobial peptide WAM-1: a promising antibacterial and anti-inflammatory drug against carbapenem-resistant Klebsiella pneumoniae
Year 2022
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4172
This work is licensed under a Creative Commons Attribution 4.0 International License.