This work is licensed under a Creative Commons Attribution 4.0 International License.
Jindongenin-1a
General Information
DRACP ID DRACP02329
Peptide Name Jindongenin-1a
Sequence DSMGAVKLAKLLIDKMKCEVTKAC
Sequence Length 24
PubChem CID Not available
Origin Amolops jingdongensis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=46 µM | MTT assay | 48 h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=40 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=150 µM; Rabbit erythrocytes: 50% Hemolysis=150 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys18<--->Cys24
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C111H199N29O33S4
Absent amino acids FHNPQRWY
Common amino acids K
Mass 300668
Pl 8.8
Basic residues 5
Acidic residues 3
Hydrophobic residues 9
Net charge 2
Boman Index -1658
Hydrophobicity 27.5
Aliphatic Index 101.67
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 5.43
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21816202
Title Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis
Doi 10.1016/j.biochi.2011.07.021
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4194
This work is licensed under a Creative Commons Attribution 4.0 International License.