Peptide Libraray

Palustrin-2AJ1

General Information

DRACP ID DRACP02330

Peptide Name Palustrin-2AJ1

Sequence GFMDTAKNVAKNVAVTLIDKLRCKVTGGC

Sequence Length 29

UniProt ID G3ETQ3 G3F829 G3F830

PubChem CID Not available

Origin Amolops jingdongensis

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
K562	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia	Leukemia	IC50=58 µM	MTT assay	48 h	1
HT-29	Colon adenocarcinoma	Carcinoma	IC50=57 µM	MTT assay	48 h	1

Hemolytic Activity Human erythrocytes: 50% Hemolysis=150 µM; Rabbit erythrocytes: 50% Hemolysis=150 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antibacterial; Antifungal

Structure Information

PDB ID Not available

Predicted Structure DRACP02330

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys23<--->Cys29

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C131H226N38O39S3

Absent amino acids EHPQSWY

Common amino acids KV

Mass 355329

Pl 9.6

Basic residues 5

Acidic residues 2

Hydrophobic residues 11

Net charge 3

Boman Index -2849

Hydrophobicity 22.76

Aliphatic Index 90.69

Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: >10 hour

Extinction Coefficient cystines 125

Absorbance 280nm 4.46

Polar residues 10

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 21816202

Title Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis

Doi 10.1016/j.biochi.2011.07.021

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_4195