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Nile tilapia piscidin 1, TP1
General Information
DRACP ID DRACP02331
Peptide Name Nile tilapia piscidin 1, TP1
Sequence FDWDSVLKGVEGFVRGYF
Sequence Length 18
UniProt ID L0CML7
PubChem CID Not available
Origin Oreochromis niloticus
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | Low active up to 100 µg/ml | MTS assay | 24 h | 1 |
| RAW 264.7 | Mouse leukemia | Leukemia | Low active up to 100 µg/ml | MTS assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: Not active up to 100 µg/ml; Tilapia erythrocytes: Not active up to 100 µg/ml
Normal (non-cancerous) Cytotoxicity TO2: Not active up to 100 µg/ml; MRC-5: Low active up to 100 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C102H141N23O27
Absent amino acids ACHIMNPQT
Common amino acids FGV
Mass 242478
Pl 4.37
Basic residues 2
Acidic residues 3
Hydrophobic residues 8
Net charge -1
Boman Index -1713
Hydrophobicity 9.44
Aliphatic Index 70
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 6990
Absorbance 280nm 411.18
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23226256
Title Five different piscidins from Nile tilapia, Oreochromis niloticus: analysis of their expressions and biological functions
Doi 10.1371/journal.pone.0050263
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4196
This work is licensed under a Creative Commons Attribution 4.0 International License.