Peptide Libraray

Nile tilapia piscidin 3, TP3

General Information

DRACP ID DRACP02333

Peptide Name Nile tilapia piscidin 3, TP3

Sequence FIHHIIGGLFSVGKHIHSLIHGH

Sequence Length 23

UniProt ID L0CMD2

PubChem CID Not available

Origin Oreochromis niloticus

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	~80% Killing=40 µg/ml	MTS assay	24 h	1
RAW 264.7	Mouse leukemia	Leukemia	~60% Killing=60 µg/ml	MTS assay	24 h	1

Hemolytic Activity Human erythrocytes: 100% Hemolysis=25 µg/ml; Tilapia erythrocytes: 42% Hemolysis=100 µg/ml

Normal (non-cancerous) Cytotoxicity TO2: 50% Cell death=80 µg/ml; MRC-5: ~50% Cell death=50 µg/ml

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antibacterial; Antiviral

Structure Information

PDB ID Not available

Predicted Structure DRACP02333

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C121H182N36O26

Absent amino acids ACDEMNPQRTWY

Common amino acids H

Mass 294962

Pl 9.71

Basic residues 7

Acidic residues 0

Hydrophobic residues 10

Net charge 7

Boman Index 789

Hydrophobicity 59.13

Aliphatic Index 131.3

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 6

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 23226256

Title Five different piscidins from Nile tilapia, Oreochromis niloticus: analysis of their expressions and biological functions

Doi 10.1371/journal.pone.0050263

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_4198