This work is licensed under a Creative Commons Attribution 4.0 International License.
Esculentin-2CHa
General Information
DRACP ID DRACP02336
Peptide Name Esculentin-2CHa
Sequence GFSSIFRGVAKFASKGLGKDLAKLGVDLVACKISKQC
Sequence Length 37
UniProt ID D3UA61
PubChem CID Not available
Origin Lithobates chiricahuensis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | LC50=10 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=150 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys31<--->Cys37
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C173H289N47O47S2
Absent amino acids EHMNPTWY
Common amino acids K
Mass 448594
Pl 10.51
Basic residues 7
Acidic residues 2
Hydrophobic residues 16
Net charge 5
Boman Index -1972
Hydrophobicity 37.3
Aliphatic Index 97.57
Half Life
Mammalian: 0.8 hour
Yeast: 10 min
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 3.47
Polar residues 11
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23159562
Title Esculentin-2CHa: a host-defense peptide with differential cytotoxicity against bacteria, erythrocytes and tumor cells
Doi 10.1016/j.peptides.2012.11.004
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4229
This work is licensed under a Creative Commons Attribution 4.0 International License.