This work is licensed under a Creative Commons Attribution 4.0 International License.
Esculentin-2CHa [D20K,D27K]
General Information
DRACP ID DRACP02337
Peptide Name Esculentin-2CHa [D20K,D27K]
Sequence GFSSIFRGVAKFASKGLGKKLAKLGVKLVACKISKQC
Sequence Length 37
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | LC50=3 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=11 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C177H303N49O43S2
Absent amino acids DEHMNPTWY
Common amino acids K
Mass 451210
Pl 11.26
Basic residues 9
Acidic residues 0
Hydrophobic residues 16
Net charge 9
Boman Index -1338
Hydrophobicity 35.14
Aliphatic Index 97.57
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 3.47
Polar residues 11
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23159562
Title Esculentin-2CHa: a host-defense peptide with differential cytotoxicity against bacteria, erythrocytes and tumor cells
Doi 10.1016/j.peptides.2012.11.004
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4386
This work is licensed under a Creative Commons Attribution 4.0 International License.