Esculentin-2CHa [C31S, C37S]

General Information


DRACP ID  DRACP02338

Peptide Name   Esculentin-2CHa [C31S, C37S]

Sequence  GFSSIFRGVAKFASKGLGKDLAKLGVDLVASKISKQS

Sequence Length  37

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A549 Lung adenocarcinoma Carcinoma LC50=26 μM CellTiter-Glo Luminescent Cell Viability assay 24 h 1

Hemolytic Activity  Human erythrocytes: 50% Hemolysis>200 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02338

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C173H289N47O49

Absent amino acids  CEHMNPTWY

Common amino acids  KS

Mass  445380

Pl  11.09

Basic residues  7

Acidic residues  2

Hydrophobic residues  16

Net charge  5

Boman Index  -2908

Hydrophobicity  19.46

Aliphatic Index  97.57

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  11

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 23159562

Title  Esculentin-2CHa: a host-defense peptide with differential cytotoxicity against bacteria, erythrocytes and tumor cells

Doi 10.1016/j.peptides.2012.11.004

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_4387

DRACP is developed by Dr.Zheng's team.