This work is licensed under a Creative Commons Attribution 4.0 International License.
Esculentin-2CHa (7–37)
General Information
DRACP ID DRACP02339
Peptide Name Esculentin-2CHa (7–37)
Sequence RGVAKFASKGLGKDLAKLGVDLVACKISKQC
Sequence Length 31
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | LC50>100 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>200 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys25<--->Cys31
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C141H247N41O39S2
Absent amino acids EHMNPTWY
Common amino acids K
Mass 374021
Pl 10.51
Basic residues 7
Acidic residues 2
Hydrophobic residues 13
Net charge 5
Boman Index -2474
Hydrophobicity 18.39
Aliphatic Index 103.87
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 4.17
Polar residues 8
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23159562
Title Esculentin-2CHa: a host-defense peptide with differential cytotoxicity against bacteria, erythrocytes and tumor cells
Doi 10.1016/j.peptides.2012.11.004
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4389
This work is licensed under a Creative Commons Attribution 4.0 International License.