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PsT-1
General Information
DRACP ID DRACP02340
Peptide Name PsT-1
Sequence KPPPWVPV
Sequence Length 8
UniProt ID C0HJF6
PubChem CID Not available
Origin Phyllomedusa sauvagii
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| LNCaP | Prostate carcinoma | Carcinoma | ~50% Cell death=10 µM | MTT assay | 72 h | 1 |
| DU145 | Prostate carcinoma | Carcinoma | ~25% Cell death=10 µM | MTT assay | 72 h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | ~25% Cell death=10 µM | MTT assay | 72 h | 1 |
Hemolytic Activity Horse erythrocytes: Not active up to 160 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C47H70N10O9
Absent amino acids ACDEFGHILMNQRSTY
Common amino acids P
Mass 104416
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 3
Net charge 1
Boman Index 486
Hydrophobicity -35
Aliphatic Index 72.5
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 785.71
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23518460
Title PsT-1: a new tryptophyllin peptide from the skin secretion of Waxy Monkey Leaf Frog, Phyllomedusa sauvagei
Doi 10.1016/j.regpep.2013.03.017
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4274
This work is licensed under a Creative Commons Attribution 4.0 International License.