Cliotides T7, CT7

General Information


DRACP ID  DRACP02341

Peptide Name   Cliotides T7, CT7

Sequence  GIPCGESCVFIPCTVTALLGCSCKDKVCYKN

Sequence Length  31

UniProt ID  G1CWH5  P86903 

PubChem CID  Not available

Origin  Clitoria ternatea

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A549 Lung adenocarcinoma Carcinoma IC50=0.73 µM MTT assay 72 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02341

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys4<--->Cys21; Cys8<--->Cys23; Cys13<--->Cys28; NCB: Gly1<--->Asn31

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C139H227N35O42S6

Absent amino acids  HMQRW

Common amino acids  C

Mass  378821

Pl  7.73

Basic residues  3

Acidic residues  2

Hydrophobic residues  9

Net charge  1

Boman Index  -381

Hydrophobicity  57.74

Aliphatic Index  81.61

Half Life 
  Mammalian: 1.3 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  1865

Absorbance 280nm  62.17

Polar residues  15

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 23419988

Title  Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells

Doi 10.3892/ol.2012.1042

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPR_4279

DRACP is developed by Dr.Zheng's team.