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Cliotides T7, CT7
General Information
DRACP ID DRACP02341
Peptide Name Cliotides T7, CT7
Sequence GIPCGESCVFIPCTVTALLGCSCKDKVCYKN
Sequence Length 31
PubChem CID Not available
Origin Clitoria ternatea
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=0.73 µM | MTT assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys4<--->Cys21; Cys8<--->Cys23; Cys13<--->Cys28; NCB: Gly1<--->Asn31
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C139H227N35O42S6
Absent amino acids HMQRW
Common amino acids C
Mass 378821
Pl 7.73
Basic residues 3
Acidic residues 2
Hydrophobic residues 9
Net charge 1
Boman Index -381
Hydrophobicity 57.74
Aliphatic Index 81.61
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 1865
Absorbance 280nm 62.17
Polar residues 15
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23419988
Title Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4279
This work is licensed under a Creative Commons Attribution 4.0 International License.