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Cliotides T10, CT10
General Information
DRACP ID DRACP02342
Peptide Name Cliotides T10, CT10
Sequence GVPCAESCVWIPCTVTALLGCSCKDKVCYLN
Sequence Length 31
UniProt ID P86842
PubChem CID Not available
Origin Clitoria ternatea
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=0.7 µM | MTT assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys4<--->Cys21; Cys8<--->Cys23; Cys13<--->Cys28; NCB: Gly1<--->Asn31
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C141H227N35O42S6
Absent amino acids FHMQR
Common amino acids C
Mass 381224
Pl 6.03
Basic residues 2
Acidic residues 2
Hydrophobic residues 11
Net charge 0
Boman Index 600
Hydrophobicity 76.77
Aliphatic Index 94.19
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 7365
Absorbance 280nm 245.5
Polar residues 14
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23419988
Title Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4280
This work is licensed under a Creative Commons Attribution 4.0 International License.