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Cliotides T12, CT12
General Information
DRACP ID DRACP02343
Peptide Name Cliotides T12, CT12
Sequence GIPCGESCVYIPCTVTALLGCSCKDKVCYKN
Sequence Length 31
UniProt ID C0HKG2
PubChem CID Not available
Origin Clitoria ternatea
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=0.78 µM | MTT assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys4<--->Cys21; Cys8<--->Cys23; Cys13<--->Cys28; NCB: Gly1<--->Asn31
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C139H227N35O43S6
Absent amino acids FHMQRW
Common amino acids C
Mass 380421
Pl 7.73
Basic residues 3
Acidic residues 2
Hydrophobic residues 8
Net charge 1
Boman Index -693
Hydrophobicity 44.52
Aliphatic Index 81.61
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 3355
Absorbance 280nm 111.83
Polar residues 16
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23419988
Title Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4281
This work is licensed under a Creative Commons Attribution 4.0 International License.