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DP1
General Information
DRACP ID DRACP02348
Peptide Name DP1
Sequence RRQRRTSKLMKRGGKLAKLAKKLAKLAKLAK
Sequence Length 31
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Coupling peptide Pro-apoptotic peptide Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCA 205 | Mouse fibrosarcoma | Carcinoma | LC50<50 μM | MTT assay | 3 h | 1 |
| Clinical isolate 4129 | Human neck tumor | Carcinoma | LC50<50 μM | MTT assay | 3 h | 1 |
| Clinical isolate 22B | Human head tumor | Carcinoma | LC50<50 μM | MTT assay | 3 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism It is possible that the DP1 fusion peptide can be used to facilitate an immune response against tumor antigens by triggering massive apoptosis within tumors
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C156H296N56O35S
Absent amino acids CDEFHINPVWY
Common amino acids K
Mass 408378
Pl 13.13
Basic residues 14
Acidic residues 0
Hydrophobic residues 11
Net charge 14
Boman Index -9326
Hydrophobicity -95.81
Aliphatic Index 91.61
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 11691780
Title A proapoptotic peptide for the treatment of solid tumors
Doi Not available
Year 2001
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4305
This work is licensed under a Creative Commons Attribution 4.0 International License.