This work is licensed under a Creative Commons Attribution 4.0 International License.
Pro-apoptotic peptide, PAP
General Information
DRACP ID DRACP02355
Peptide Name Pro-apoptotic peptide, PAP
Sequence KLAKLAKKLAKLAK
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | 82% Killing=10 µM ; 100% Killing=50 µM | CellTox cytotoxicity assay | 30 min | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C72H138N20O15
Absent amino acids CDEFGHIMNPQRSTVWY
Common amino acids K
Mass 175610
Pl 11.5
Basic residues 6
Acidic residues 0
Hydrophobic residues 8
Net charge 6
Boman Index -638
Hydrophobicity -7.14
Aliphatic Index 140
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26734838
Title Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.