Pro-apoptotic peptide, PAP

General Information


DRACP ID  DRACP02355

Peptide Name   Pro-apoptotic peptide, PAP

Sequence  KLAKLAKKLAKLAK

Sequence Length  14

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Membrane lysis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MDA-MB-231 Breast adenocarcinoma Carcinoma 82% Killing=10 µM ; 100% Killing=50 µM CellTox cytotoxicity assay 30 min 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02355

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C72H138N20O15

Absent amino acids  CDEFGHIMNPQRSTVWY

Common amino acids  K

Mass  175610

Pl  11.5

Basic residues  6

Acidic residues  0

Hydrophobic residues  8

Net charge  6

Boman Index  -638

Hydrophobicity  -7.14

Aliphatic Index  140

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 26734838

Title  Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy

Doi 10.18632/oncotarget.6794

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.