C-D-PAP

General Information


DRACP ID  DRACP02357

Peptide Name   C-D-PAP

Sequence  Cklaklakklaklak

Sequence Length  15

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Membrane lysis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HepG2 Hepatoblastoma Blastoma LD50>256 µg/ml; 32% Killing=250 µg/ml CCK-8 assay 48 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  k=D-Lys; l=D-Leu; a=D-Ala

Chiral  Mix



Physicochemical Information


Formula  C3H-21NO-12S

Absent amino acids  ADEFGHIKLMNPQRSTVWY

Common amino acids  C

Mass  11882

Pl  5.92

Basic residues  0

Acidic residues  0

Hydrophobic residues  0

Net charge  0

Boman Index  128

Hydrophobicity  16.67

Aliphatic Index  0

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 33335804

Title  Addition of L-cysteine to the N- or C-terminus of the all-D-enantiomer [D(KLAKLAK)2] increases antimicrobial activities against multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Escherichia coli

Doi 2020

Year 

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.