This work is licensed under a Creative Commons Attribution 4.0 International License.
C-D-PAP
General Information
DRACP ID DRACP02357
Peptide Name C-D-PAP
Sequence Cklaklakklaklak
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | LD50>256 µg/ml; 32% Killing=250 µg/ml | CCK-8 assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification k=D-Lys; l=D-Leu; a=D-Ala
Chiral Mix
Physicochemical Information
Formula C3H-21NO-12S
Absent amino acids ADEFGHIKLMNPQRSTVWY
Common amino acids C
Mass 11882
Pl 5.92
Basic residues 0
Acidic residues 0
Hydrophobic residues 0
Net charge 0
Boman Index 128
Hydrophobicity 16.67
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33335804
Title Addition of L-cysteine to the N- or C-terminus of the all-D-enantiomer [D(KLAKLAK)2] increases antimicrobial activities against multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Escherichia coli
Doi 2020
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.